Speaker 0:  sci fi just lots its fiction tag. researchers just prove we can stop a brain's molecular clock, freeze it to a 100 and negative a 196 degrees celsius, and successfully reboot its ability to learn and form memories. this isn't just about cryonics. it's the first step forward toward an amazon prime for human organ transplant. so we've just successfully, tested the brain pause button. scientists at fau germany vitrified mouse brain tissue, the hippocampus, into a glass like state, stored at cryogenic temperatures, and revived it with full electrical and synaptic function. in the most rigorous proof to date, the biological machinery of memory can survive a deep freeze. so this effectively proves that biological time travel is molecularly possible, potentially ending the race against the clock for organ transplants and brain research. what do you think about this, john?

Speaker 1:  yeah. i can't believe you said amazon prime. it this, for some reason, when i think of this, i think of demolition man and that instant freeze thing that happens in the movie. yeah. but yeah. so i think i think this is really cool. i like how they're going with this. my question or the thought that i had is the people who are already cryogenically frozen currently to preserve themselves, were they preserved in this way, or are they kind of maybe screwed for being, unthawed in the future? but what i liked about this, was that, they they proved that they tested well, they tested the hippocampus. so the experiment focused on 350 micron slices of mouse hippocampus, which is the region responsible for learning, memory formation, and spatial navigation. after thawing, they observed intact neuronal membranes and synapses, active mitochondria, which is energy production still working, and near normal electrical signaling. so this is crucial because it shows not just survival, but functional recovery. so, i think this is a big deal because the brain is probably the most fragile organ in the body. right? so normally, freezing will destroy it due to ice crystals. but the researchers used a special method, like you said, called vitrification, which basically turns the brain into what you said is a glass like state instead of forming ice. and so, when they thought it, the neurons fire electrical signals, they maintain connections, and they showed signs of learning related activity. now bottom line here is we're not reviving frozen humans anytime soon, but this is a serious step towards preserving brain function and maybe one day even consciousness, which i think is really cool. what are your thoughts on this, greg?

Speaker 0:  well, when i called it the amazon prime, i did that because the problem with organs right now is they don't last very long. so you have a very limited window when a human dies to get their organs to the next human because they only survive so long. but now if you can freeze dry the organs, of everybody and they'll last potentially forever in the freezer, now we can say, hey. next day delivery of any organ anytime, you know, because here we go.

Speaker 1:  it's gonna be on the brain then. okay. okay. i get it.

Speaker 0:  you know? so, i mean, ideally, if you can do it to the brain, you can do it to anything else. think of this like a high end video game. normal freezing is like smashing the console with a hammer. the ice crystals physically tear the hardware apart. vitrification is like hitting the save and power drain. the v three crypto protectant acts like a digital backup keeping the data intact when you hit the power on. the game resumes exactly where you left off, high scores and all. so we're currently in the laboratory phase, human organ banking applications, you know, five to ten years from now, but it's really cool that, where we are right now. this is a massive leap, in neuroscience, reproducibility. labs can now live functioning brain tissues across the world, for disease research without, dying in transit. right?

Speaker 1:  yeah. and let me quantify a few things so that you don't think we're talking about, like, a whole mouse brain. and a couple a couple limitations that were, that this research showed. there's the tissue, it only survived for a few hours post op. and it was only thin slices, not whole brains or whole animals. and there's no evidence that memories were preserved or recoverable. and scaling to a full brain is going to be much, much harder because you've got the blood brain barrier, you've got size and complexity. so right now, as of right now, even researchers have admitted that whole brain revival is still far beyond the current capability. but like you said, maybe this could be used in other organs. right?

Speaker 0:  yeah. the tissue slices were 350 micrometer, i guess, thickness, optimized for chemical penetration. they were vitrified at, like we said, at hun negative a 196 degrees celsius and stored at, negative a 140 degrees celsius. and the success rate is one third success in reviving hippocampal circuits within a whole mouse, brain. so, you know, we'll have to see when they start, migrating that. the breakthrough relies on the virtual rotation you talked about. this is the most significant validation of functional neurorecovery since the first successful of cryopreservation of a kidney moved the goalpost from structural preservation to functional revival. so they're, relating this to now how much we can do with the kidney and taking this to the next level. so, long term potentiation or ltp recovered in this study is the cellular equivalent of a hard drive's read write capability. without it, the brain is just a library, where no one can, check out books. so getting it to do impulses, you know, means it's functioning at some level. the research was published in, pnas, which is a scientific equivalency of winning a pollster. it signals that the cryomedicine is moving from the fringes of, silicon valley billionaire hobbies into mainstream. and to revive the tissue, researchers had to warm it faster than they cooled it. if the warming is too slow, the glass can turn back to ice, recrystallization, essentially blending the brain from inside out during the thaw. so, you know, it's not without its risks. the 22% metabolic drop is significant. while the tissue can learn, we don't know if the chemical toxicity of the v three solution causes long term cellular dementia or dna fragmentation. so if this scales to a full mouse heart or a kidney with a hundred percent recovery, the organ donor waiting list might become a thing of the past. yeah. so we've officially moved from wondering if neural function can survive the deep freeze to figuring out how to scale it to a human level. if you could freeze your brain today to wake up in a hundred years, but there was a 22% chance your processing power would be permanently throttled. would you take the jump? let us know in the chat.