Speaker 0:  if you've ever felt like a complete zombie after a long international fight, you need to hear this. scientists have just discovered a compound that could literally be a reset button for your biological clock. we are looking at a breakthrough compound currently called myc six two eight. this isn't another weak herbal supplement. it's a chemical developed by researchers in japan that target the molecular machinery of your body's clock. in early testing, it cut jet lag recovery time by nearly half, potentially solving one of the biggest headaches of modern travel and shift work. what do you think is going on here, john? what do you think about this?

Speaker 1:  i love this. i love it because this would've been great for when i was traveling over to europe with the six, five, six, seven hour difference. but i liked it because it this is interesting because it could help a lot of people who suffer from jet lag. now, before we dive into this, i know that there are some planes like the boeing dreamliner and different things like that that have implemented systems and air systems, circulation systems into their plane to help with jet lag, and apparently that does help. but, right now, the best way to overcome jet lag is to stay up for twenty four hours and then take the red eye. there's a bunch of strategies. right? so i like this because, there's a potential, not cure, but a potential solution. so the way it works is it activates per one, which is one of the central clock genes, and it binds to c r y one, which is a protein that normally supresses per one activity. so when the mic six two eight binds cry one, it removes that suppression, and that allows, per one to be expressed. and this leads to an advanced in the circadian phase, which means the portion of the twenty four hour cycle that controls sleep and behavior shifts earlier, essentially. so, unlike light therapy or melatonin, which depend essentially on precise timing to be effective, mic six two eight produces essentially a time independent phase advance. so it reliably moves the clock forward regardless of when it's taken. now what does this do to the brain? what does this do to the body? i don't know. obviously, there's gonna have to be some testing that has to be done. what are the long term effects? but if there aren't any long term effects, it can't be worse than not getting any sleep for forty eight hours. i don't know. think? do you think this is a safe thing to take?

Speaker 0:  well, i mean, it's early. yeah. right? because the control group and testing is mostly mice. so is it safe to take? i i wouldn't be jumping on the bandwagon first. but i sit back and say, you know, jet lag's one thing. the shift work thing is interesting, but people often end up, with their sleeping out of whack. yeah. you know, they're they wake up in the middle of the night all the time. i wonder if this will evolve into a treatment where you can reset your clock back to proper sleep cycle for regular individuals that just get out of whack. so i like the concept. i like where it's going. i like what i'm hearing about it.

Speaker 1:  yeah.

Speaker 0:  but, it's got a long way to go before i think i'd i'd, take it.

Speaker 1:  yeah. yeah. that's true. but, like, i like that there's a potential solution because right now, there's very limited approaches to help with jet lag, and it's it affects a lot of people. and for those of you that don't really understand what jet lag is or haven't traveled and experienced it, it's not just feeling tired. it's the result of the body's clock being out of sync with environmental time cues. and so this affects hormones like melatonin, body temperature, rhythms, digestion, and alertness. so if this could help change that quickly, this would be great. so, but the other thing to think about too is if this resets your circadian clock, so could it not help with a sleep disorder or people who have shift work health issues or other misalignment conditions?

Speaker 0:  that's exactly what i was talking about. so yeah. i'd love to see it. so it it solves the internal desynchrony problem. you know, what you're referring to is where your brain, liver, and muscles are all operating at different time zone, and it forces them all to sync up and move forward together. you know, this could impact your life recover from a new york to london flight in two days instead of the usual four to five. you mentioned nurses or factory workers could shift from day to night shifts without the week long brain fog. athletes and business executives can land and be ready to perform at a 100% faster for, like, pro, leagues and stuff. so this is a preclinical phase tested on mice. it'll likely take years of safety testing before, it hits a pharmacy, but i really like it. and, you know, it works by advancing the clock. this makes it amazing for traveling, east, like us to europe, but potentially less useful or more complicated traveling west. so we'll have to see what that means. and, safety is a big concern. the drug manipulates genes and proteins deep inside your cells. critics and regulators, will need to be a 100% sure that messing with these core biological mechanism doesn't cause toxicity or raise cancer risk, before you even start taking it. yeah. so, nick six twenty eight produces a unidirectional phase advance. it consistently moves the clock forward regardless of when it's administered. this is the first time we've seen a potential drug that fixes the root cause of jet lag inside your cells rather than masking the symptoms. and, you know, would you take a pill to hack your biology and to skip the jet lag, or does messing with your genes sound a little too risky? let us know what you think in the comments, and we'll continue to watch this story.